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You are here:Home » Antibodies » Abs to HLA » Anti -HLA Class 2 Antigen DR1 (HLA DR1 Class II, HLA-DR1)

Anti -HLA Class 2 Antigen DR1 (HLA DR1 Class II, HLA-DR1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B FC
HLA-DR1 belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28kD. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. The antibody MEM-267 specifically binds to the empty but not peptide-loaded form of HLA-DR1.
Catalog #H6099-97R
ApplicationsSuitable for use in Flow Cytometry, ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone NoMEM-267
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 15mM sodium azide, pH7.4.
PurityPurified
ImmunogenPurified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
SpecificityRecognizes human HLA-DR1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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