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You are here:Home » Antibodies » Antibodies-HLA » Anti -HLA Class 2 Antigen DP, DQ, DR

Anti -HLA Class 2 Antigen DP, DQ, DR


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Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
The human leukocyte antigen (HLA) system, also known as Major histocompatibilty complex is a group of genes residing on chromosome 6 and encodes cell surface antigens which process and present antigens to T helper cells.They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. The HLA system is classified into two types, class I antigen (A, B, and C) which present peptides from inside the cells and class II antigen which present phagocytosed antigens peptides from outside the cells to T-lymphocytes. MHC class II molecules, is a transmembrane glycoprotein composed of an alpha chain (36kD) and a beta chain (27kD). Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. Thus they have a critical role in the initiation of the immune response.
Catalog #H6099-98H
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:25-1:50
Optimal dilutions to be determined by the researcher.
Positive ControlTonsil
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No11E219
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
ImmunogenTonsil cells. Cellular Localization: Cell membrane.
SpecificityRecognizes human HLA-DR, DP, DQ.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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