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You are here:Home » Antibodies » Abs to Coenzyme A » Anti -HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-Coenzyme A reductase, LDLCQ3, HMGCR)

Anti -HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-Coenzyme A reductase, LDLCQ3, HMGCR)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Catalog #H6201-01A
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA:1:8000
Optimal dilutions to be determined by the researcher.
Positive ControlHuman Brain (Cerebellum), Liver, Skeletal Muscle and Adipose lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-ADPSPQNSTADTSK, from the internal region of human HMG-CoA Reductase (NP_000850).
SpecificityRecognizes human HMG-CoA Reductase.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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