You are here:Home
»
Antibodies
»
Abs to Coenzyme A
»
Anti -HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-coenzyme A Reductase, 3-hydroxy-3-methylglutaryl-CoA Reductase, HMGCR, LDLCQ3)
Anti -HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-coenzyme A Reductase,
3-hydroxy-3-methylglutaryl-CoA Reductase, HMGCR, LDLCQ3)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
E B IH |
|
| HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. | | | Catalog # | H6201-01B | | Applications | Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested. | | Recommended Dilutions | ELISA: 1:1000 | | Immunohistochemistry (FFPE): 1:50-1:100 | | Western Blot: 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide | | Purity | Purified by ammonium sulfate precipitation. | | Immunogen | Synthetic peptide corresponding to a region between aa380-410 from the center region of human HMG-CoA Reductase, conjugated to KLH. | | Specificity | Recognizes human HMG-CoA Reductase at ~97.5kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | EC=1.1.1.34 |
External Links
|
