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You are here:Home » Antibodies » Abs to Biochemicals » Anti -4-Hydroxynonenal, Conjugated (4-HNE, HNE, 4-Hydroxy-2-nonenal)

Anti -4-Hydroxynonenal, Conjugated (4-HNE, HNE, 4-Hydroxy-2-nonenal)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Serum E B
4-Hydroxynonenal is a A 65 kD, highly reactive aldehyde released upon oxidation of omega-6-insaturated fatty acids, often by free radicals. HNE acts to spread and increase the initial effects of free radical events. It binds nucleic acids, phospholipids and sulfhydryl, histidine and lysine groups. These conjugates cause the cytotoxic effects (including cell death) that occur during oxidative stress due to hydrogen peroxide, superoxide, UV, heat and oxidant chemicals. HNE plays a role in the pathogenesis of diseases, stimulating fibrogenesis and inflammation. It is thought to act as a sensor of external stimuli, inducing the stress response by modulating membrane receptors such as Epidermal growth factor receptor or Fas.
Catalog #H6275-02
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 1:10,000
Western Blot: 1:3000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
ConcentrationNot Determined
FormSupplied as a liquid, 0.1% sodium azide
PuritySerum
Immunogen4-Hydroxynonenal conjugate
SpecificityRecognizes 4-Hydroxynonenal.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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