Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Syntaxin, Synaptotagmin, Synaptophysin » Anti -hnRNP Q/R (Heterogeneous Nuclear Ribonucleoprotein Q, hnRNP Q, hnRNP-Q, HNRPQ, HNRPQ1, Heterogeneous Nuclear Ribonucleoprotein R, hnRNP R, HNRNPR, hnRNP-R, HNRPR, Glycine- and Tyrosine-rich RNA-binding Protein, GRYRBP, GRY-RBP, NS1-associated Protein 1, N

Anti -hnRNP Q/R (Heterogeneous Nuclear Ribonucleoprotein Q, hnRNP Q, hnRNP-Q, HNRPQ,
HNRPQ1, Heterogeneous Nuclear Ribonucleoprotein R, hnRNP R, HNRNPR, hnRNP-R, HNRPR,
Glycine- and Tyrosine-rich RNA-binding Protein, GRYRBP, GRY-RBP, NS1-associated Protein 1,
N

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Heterogeneous nuclear ribonucleoprotein Q and R belong to a family of hnRNP proteins that are involved in RNA binding, RNA biosynthesis and mRNA transport from nucleus to cytoplasm (1-3). These two proteins are encoded by different gene but have 83% homology. hnRNP
Q has three alternative splice variants (hnRNP Q1-3) (1-3). Methylation of carboxy-terminal arginine residues is required for nuclear localization (4). hnRNP Q binds to AUrich mRNA in conjunction with AUF1 and regulates mRNA decay (5). hnRNP Q isoforms play a crucial role in mediating nuclear function of survival of motor neuron (SMN) complex (6,7) and modulate RNA biosynthesis and hepatitis C virus replication (8). hnRNP R was identified recently and its function is still under investigation (9), however hnRNP R does not duplicate the biological function of hnRNP Q. Both hnRNP Q and R are present in cytoplasmic mRNP granules containing untranslated mRNAs (10) and both interact with SMN (11).
Catalog #H6285-68
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000 Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight.
Immunoprecipitation: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to residues near the carboxy terminus of human hnRNP Q.
SpecificityRecognizes endogenous levels of total hnRNP Q and hnRNP R.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesSynaptotagmin Binding, Cytoplasmic RNA Interacting Protein, dJ3J17.2, FLJ25714, FLJ31626


External Links