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You are here:Home » Antibodies » Abs to Biochemicals » Anti -Homocysteine

Anti -Homocysteine

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
Homocysteine a sulfur containing amino acid, is formed by the transmethylation of methionine, an essential amino acid. Homocysteine may be irreversibly metabolised to cystathionine by cystathionine synthetase. This reaction uses pyridoxal phosphate (Vitamin B6) as a co-enzyme (see figure). The enzyme cystathionine synthetase is deficient in homocysteinuria, a rare genetic disease associated with high blood levels of homocysteine and the development of premature atherosclerosis. This and the association of other rare enzyme deficiencies with homocysteinemia and premature atherosclerosis led McCully to formulate the homocysteine hypothesis of atherosclerosis (McCully KS, The homocysteine theory of atherosclerosis. Atherosclerosis. 1976; 20: 23-27)
Catalog #H6950-10
ApplicationsSuitable for use in ELISA. Other applications have not been tested.
Recommended DilutionsELISA: 1:2500-1:5000
Optimal dilutions to be determined by the researcher.
Compound Crossreactivity RatioHomocysteine-G-BSA 1
Cysteine-G-BSA 1:450
Homocysteic acid-G-BSA >1:100,000
G Glutaraldehyde
BSA: Bovine Serum Albumin
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS NumberN/A
Clone TypePolyclonal
IsotypeIgG
HostRabbit
ConcentrationNot Determined
FormSupplied as a liquid in PBS, pH 7.1, 0.1% sodium azide.
PuritySerum
ImmunogenHomocysteine-Glutaraldehyde conjugated to BSA
SpecificityRecognizes Homocysteine
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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