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You are here:Home » Antibodies » Abs to Enzymes, Lipase » Anti -Hormone Sensitive Lipase, phosphorylated (Ser855) (HSL, Lipase Hormone Sensitive, LHS, LIPE)

Anti -Hormone Sensitive Lipase, phosphorylated (Ser855) (HSL, Lipase Hormone Sensitive,
LHS, LIPE)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization, overall energy
homeostasis, and possibly steroidogenesis.It is acutely controlled through reversible phosphorylation by catecholamines and insulin (1).HSL is the rate-limiting enzyme in hydrolysis of triglycerides in adipose tissue and of cholesteryl esters in steroidogenic tissues including the
adrenals, ovaries, testes, and macrophages (2, 3).HSL activity has been positively correlated with free and esterified cholesterol ratios in seminiferous tubules (STf) and interstitial tissue (ITf) enriched fractions, but not with triglyceride levels, during testicular development.HSL is localized to elongated spermatids and Sertoli cells, where its distribution is stage-dependent, and within the cells lining the excurrent ducts of the testis.The HSL protein levels and enzymatic activity in
ITf and STf were reported positively correlated with serum testosterone levels during development (4).
Applications:
Suitable for use in Western Blot. Other applications not tested.
Catalog #H7021-85
Recommended DilutionWestern Blot: 1:1000-1:5000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H389
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% glycerol, 0.01% sodium
azide and 0.05% BSA.
PuritySupernatant
ImmunogenA phospho-specific peptide corresponding to residues surrounding Serine 855 of human HSL.
SpecificityRecognizes human HSL when phosphorylated at Ser855. Species Crossreactivity: Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesHormone Sensitive Lipase Testicular Isoform


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