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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -HRD1 (1200010C09Rik, KIAA1810, MGC40372, Synovial Apoptosis Inhibitor 1 Synoviolin, Synoviolin 1)

Anti -HRD1 (1200010C09Rik, KIAA1810, MGC40372, Synovial Apoptosis Inhibitor 1 Synoviolin,
Synoviolin 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.
Catalog #H7445-50
Positive Control 293T, INS-1, and MIN6 cell lysates.
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormAs reported
PuritySerum
ImmunogenA synthetic peptide made to an internal portion of the human protein (within residues 300-400). [UniProt Q96PK3].
SpecificitySpecies Crossreactivity: Can be used to detect human and mouse proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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