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Anti -Hrs-2 (HGS, Hepatocyte Growth Factor-regulated tyrosine kinase substrate2, Hrs2, SNAP-25 Interacting Protein Hrs-2)
Anti -Hrs-2 (HGS, Hepatocyte Growth Factor-regulated tyrosine kinase substrate2, Hrs2,
SNAP-25 Interacting Protein Hrs-2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
B IP IH |
|
| Hrs/Hgs (hepatocyte growth factor-regulated tyrosine kinase substrate) is a tyrosine-phosphorylated member of a protein family characterized by a conserved 3´-phosphoinositide- interacting RING zinc finger domain, the so called FYVE finger. A variant of Hrs, Hrs-2 is an ATPase that has been shown to play a regulatory role in the docking and/or fusion of synaptic vesicles to plasma membranes through a calcium-regulated interaction with SNAP-25. Hrs-2 physically interacts with Eps15, a protein required for receptor-mediated endocytosis. The Hrs-2/Eps15 interaction is calcium dependent, inhibited by SNAP-25 and alpha-adaptin, and results in the inhibition of receptor-mediated endocytosis. Immunoelectron microscopy reveals Hrs-2 localization on the limiting membrane of multivesicular bodies, organelles in the endosomal pathway. Recent data suggest that Hrs-2 acts to provide communication between endo- and exocytic processes. | | | Catalog # | H7453-15 | | Applications | Suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry: 1:100-1:1000 | | Immunoprecipitation: 2ug/ml | | Western Blot: 1:2000-1:3000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 6D466 | | Host | Mouse | | Source | Rat | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 50% glycerol. | | Purity | Purified | | Immunogen | Recombinant full length rat Hrs-2. | | Specificity | Recognizes rat Hrs-2. Crossreactivity: Hrs (HGS). | | Species Crossreactivity | Mouse, monkey and human. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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