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You are here:Home » Antibodies » Antibodies-Growth Factors, Cytokines » Anti -Hrs-2 (HGS, Hepatocyte Growth Factor-regulated tyrosine kinase substrate2, Hrs2, SNAP-25 Interacting Protein Hrs-2)

Anti -Hrs-2 (HGS, Hepatocyte Growth Factor-regulated tyrosine kinase substrate2, Hrs2,
SNAP-25 Interacting Protein Hrs-2)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
Hrs/Hgs (hepatocyte growth factor-regulated tyrosine kinase substrate) is a tyrosine-phosphorylated member of a protein family characterized by a conserved 3´-phosphoinositide- interacting RING zinc finger domain, the so called FYVE finger. A variant of Hrs, Hrs-2 is an ATPase that has been shown to play a regulatory role in the docking and/or fusion of synaptic vesicles to plasma membranes through a calcium-regulated interaction with SNAP-25. Hrs-2 physically interacts with Eps15, a protein required for receptor-mediated endocytosis. The Hrs-2/Eps15 interaction is calcium dependent, inhibited by SNAP-25 and alpha-adaptin, and results in the inhibition of receptor-mediated endocytosis. Immunoelectron microscopy reveals Hrs-2 localization on the limiting membrane of multivesicular bodies, organelles in the endosomal pathway. Recent data suggest that Hrs-2 acts to provide communication between endo- and exocytic processes.
Catalog #H7453-15
ApplicationsSuitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry: 1:100-1:1000
Immunoprecipitation: 2ug/ml
Western Blot: 1:2000-1:3000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No6D466
FormSupplied as a liquid in PBS, pH 7.2, 50% glycerol.
PurityPurified by affinity chromatography.
ImmunogenRecombinant full length rat Hrs-2.
SpecificityRecognizes rat Hrs-2. Crossreactivity: Hrs (HGS).
Species CrossreactivityMouse, monkey and human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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