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You are here:Home » Antibodies » Abs to Enzymes, Sulfotransferase » Anti -HS6ST3 (Heparan sulfate 6-O-sulfotransferase 3)

Anti -HS6ST3 (Heparan sulfate 6-O-sulfotransferase 3)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified IH
HS6ST3 (Heparin sulfate 6-O-sulfotransferase 3) is a 60-62kD member of the sulfotransferase 6 family of enzymes. It is one of three 6-O sulfotransferase isoforms, all of which essentially perform the same function, but all of which are the products of distinct genes. HS6ST3 is known to sulfate the #6 position of glucosamine sulfate that is linked to a 2-O-sulfated iduronic acid in heparin sulfate. The molecule shows a temporal expression pattern, being found in postnatal cerebellar Purkinje cells and cerebral cortical pyramidal cells in layers II/III and V. Mouse HS6ST3 is a 470aa type II transmembrane glycoprotein. It contains a short four aa cytoplasmic N-terminus coupled to an extended 443aa lumenal domain (aa28-470). The lumenal domain contains a stem region (aa28-83) that mediates oligomerization and Golgi localization, plus a sulfotransferase enzyme domain (aa142-409). Cleavage within the stem region by b-secretase generates a soluble form of HS6ST3. Over aa28-470, mouse HS6ST3 shares 99-95aa identity with rat and human HS6ST3, respectively.
Catalog #H7520-02
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 5-15ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceMouse
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 200ug/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa28-470 from mouse HS6ST3 expressed in CHO cells (NP_056635).
SpecificityRecognizes mouse HS6ST3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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