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You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -HSC70 Interacting Protein (ST13/HIP) (AAG2, Aging Associated Protein 2, FAM10A1, FLJ27260, HSPABP1, MGC129952)

Anti -HSC70 Interacting Protein (ST13/HIP) (AAG2, Aging Associated Protein 2, FAM10A1,
FLJ27260, HSPABP1, MGC129952)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH IC FC
ST13/HIP is a cytoplasmic co-chaperone involved in the regulation of Hsc70 chaperone activity and the maturation of progesterone receptor. ST13/HIP is made of two structural and functional domains, an NH2-terminal domain, responsible for the dimerization and the overall asymmetry of the molecule, and a COOH-terminal globular domain, both involved in Hsc70 and unfolded protein binding (1). By collaborating with other positive co-factors such as Hsp40 and the Hsp70-Hsp90 organizing protein (Hop), or competing with negative co-factors such as Bcl2-associated athanogen 1 (Bag1), ST13/HIP facilitates may facilitate the chaperone function of Hsc/Hsp70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and regulators of proliferation or apoptosis (2).
Catalog #H7651-07
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:2,500-1:5,000
Immunohistochemistry: 1:100-1:250
Immunocytochemistry: 1:50-1:100
Flow cytometry: 1:20
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E350
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50 mM Tris- Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
PuritySupernatant
ImmunogenZA synthetic peptide corresponding to residues near the C-terminus of human Hsc70 Interacting Protein/HIP.
SpecificityRecognizes human ST13/HIP. Species crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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