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You are here:Home » Antibodies » Abs to Disease Markers » Anti -Huntingtin Protein, aa2703-2911 (Huntington Disease)

Anti -Huntingtin Protein, aa2703-2911 (Huntington Disease)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegeneative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.
Catalog #H7960-01
ApplicationsSuitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Frozen. Increased cytoplasmic staining, relative to nuclear, has been reported using formaldehyde as a fixative compared with acetone/methanol.
Optimal dilutions to be determined by the researcher.
Recommended Positive Control TissueBrain
Recommended Secondary AntibodyI1904-65W: IgG, F(abí)2 (HRP) Pab Rb x Mo
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No3H2241
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to aa2703-2911 of human Huntingtin Protein.
SpecificityRecognizes an epitope corresponding to the human HDC region (2703-2911 amino acids) of the Huntingtin protein. Detects a 350kD band on Western Blots but also detects smaller degradation products of Huntingtin. Recognizes both denatured and native Huntingtin in human brain. The combined use of H7960-01, H7960 and H7960-01A demonstrate that huntingtin is enriched in neuronal cells in the brain. Species Crossreactivity: rabbit and mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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