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Anti -Huntingtin Protein, aa2703-2911 (Huntington Disease)
Anti -Huntingtin Protein, aa2703-2911 (Huntington Disease)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IH |
|
| Huntington's disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegeneative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years. | | | Catalog # | H7960-01 | | Applications | Suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry: Frozen. Increased cytoplasmic staining, relative to nuclear, has been reported using formaldehyde as a fixative compared with acetone/methanol. | | Optimal dilutions to be determined by the researcher. | | Recommended Positive Control Tissue | Brain | | Recommended Secondary Antibody | I1904-65W: IgG, F(ab’)2 (HRP) Pab Rb x Mo | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 3H2241 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant protein corresponding to aa2703-2911 of human Huntingtin Protein. | | Specificity | Recognizes an epitope corresponding to the human HDC region (2703-2911 amino acids) of the Huntingtin protein. Detects a 350kD band on Western Blots but also detects smaller degradation products of Huntingtin. Recognizes both denatured and native Huntingtin in human brain. The combined use of H7960-01, H7960 and H7960-01A demonstrate that huntingtin is enriched in neuronal cells in the brain. Species Crossreactivity: rabbit and mouse | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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