Anti -HYPB (SETD2, Histone-lysine N-methyltransferase SETD2, HIF-1, Huntingtin Yeast
Partner B, Huntingtin-interacting Protein 1, HIP-1, Huntingtin-interacting Protein B,
Lysine N-methyltransferase 3A, SET Domain-containing Protein 2, hSET2, HIF1, KIAA1732, KMT
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E |
|
| SET2 is a histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. This protein probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. SET2 binds DNA at promoters, and may act as a transcription activator. SET2 binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SET2 belongs to a class of huntingtin interacting proteins characterized by WW motifs. | | | Catalog # | H7960-01G | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:8000 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human brain (Hippocampus, Cerebellum, Frontal Cortex), mouse brain and rat brain lysates | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-QKFGAVYKPKEDTE, from the C-terminus of the protein sequence according to NP_054878. | | Specificity | Recognizes HYPB. Species sequence homology: human, mouse, rat, canine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -HYPB (SETD2, Histone-lysine N-methyltransferase SETD2, HIF-1, Huntingtin Yeast Partner B, Huntingtin-interacting Protein 1, HIP-1, Huntingtin-interacting Protein B, Lysine N-methyltransferase 3A, SET Domain-containing Protein 2, hSET2, HIF1, KIAA1732, KMT |
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