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You are here:Home » Antibodies » Antibodies-Disease Markers » Anti -Huntingtin Protein (Huntington Disease)

Anti -Huntingtin Protein (Huntington Disease)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years. The HD gene product is widely expressed in human tissues, with the highest level of expression in the brain. The huntington gene product is expressed at similar levels in patients and controls, which suggests that the expansion of the polyglutamine repeat induces a toxic gain of function perhaps through interactions with other cellular proteins. Using yeast two-hybrid system Li et al., have identified a protein, HAP1 (huntington associated protein 1), that associates with huntingtin protein. The in vitro data suggest that the association between HAP1 and huntington is enhanced by increasing length of glutamine repeat.
Catalog #H7965-01B
Positive Control Lymphoblast cell line extracts
Clone TypeMonoclonal
Clone No8L321
ConcentrationAs reported
FormPBS containing 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenThe antibody was raised against a fusion protein containing 62 glutamine amino acid repeat.
SpecificitySpecies Crossreactivity: Human, Mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesHD, HD Protein, HDH, HTT, Huntington Chorea, Huntington's Disease Protein Homolog, IT15, ZHD

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