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You are here:Home » Antibodies » Abs to Carbohydrates, Glycoproteins » Anti -Hyaluronic Acid Binding Protein (Hyaluronan Binding Protein, HABP)

Anti -Hyaluronic Acid Binding Protein (Hyaluronan Binding Protein, HABP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IH IC
Hyaluronan binding protein 1 (HABP1), also known as C1qBP/C1qR and p32, is a ubiquitous acidic glycoprotein that functions in spermatogenesis and as a receptor for proinflammatory molecules (1, 2). HABP1 is synthesized with a 71 amino acid (aa) N-terminal preproprotein and a 208 aa mature region (3). The 3kD mature mouse HABP1, which contains a MAM33-like sequence, shares 90% and 99% aa sequence identity with human and rat HABP1, respectively. HABP1 assembles into a doughnut shaped trimer, with negatively charged residues asymmetrically distributed on one face lining the channel of the complex (4). HABP1 can be cleaved by cell surface MMP-14/MT1-MMP, a protease important in angiogenesis and tumor metastasis (5). Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6-9). Within the cell, HABP1 binds to molecules containing the C1q globular domain, multiple isoforms of PKC, mitochondrial Hrk, the cytoplasmic tails of adrenergic and GABA-A receptors, the mRNA splicing factor ASF/SF2, and the CBF transcription factor (10-16). Apoptosis and direct phosphorylation by Erk1/2 induces HABP1 translocation to the nucleus (17).
Catalog #H7980-30A
ApplicationsSuitable for use in ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Also AvailableH7980-30: Hyaluronic Acid Binding Protein (HABP)
H7980-30A: Hyaluronic Acid Binding Protein (HABP) Pab Rb xBo
H7980-35: Hyaluronic Acid Binding Protein (HABP) (Biotin)
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceBovine
ConcentrationNot determined
FormSupplied as a liquid, serum, before the addition of glycerol to 40%.
PurityNeat serum
ImmunogenBovine Hyaluronic Acid Binding Protein (HABP)
SpecificityRecognizes Hyaluronic Acid Binding Protein (HABP). Species Crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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