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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -IBSP (Bone Sialoprotein 2, Bone Sialoprotein II, BSP II, Cell-binding Sialoprotein, Integrin-binding Sialoprotein, BNSP)

Anti -IBSP (Bone Sialoprotein 2, Bone Sialoprotein II, BSP II, Cell-binding Sialoprotein,
Integrin-binding Sialoprotein, BNSP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Bone sialoprotein II (BSP II) exists as a secreted protein in extracellular matrix of the skeleton. BSP II is part of the small integrin binding ligand N-linked glycoprotein (SIBLING) family and its role is crucial for cell to matrix adhesion as well as between two active protein complexes. Flexible binding capacity of BSP II also allows it to rapidly associate with various proteins, calcium, and mineralized phases of developing bone. BSP II plays a central role in the initiation of hydroxyapatite microcalcification of breast cancer cells that contributes to the pathogenesis of bone metastasis. Recent evidence suggests that the downregulation of BSP II may lead to the reduced formation of metastatic lesions and bone metastasis in a human breast cancer model.
Catalog #I0468-50A
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000
Immunoprecipitation: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to residues near the amino terminus of human IBSP.
SpecificityRecognizes endogenous levels of total human IBSP. Species Crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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