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ICOS IgG2a Fc, Fusion Protein (Inducible Costimulator)
ICOS IgG2a Fc, Fusion Protein (Inducible Costimulator)
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| The inducible costimulator (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Each secondary signal from CD28 or ICOS results in a discrete cytokine secretion profile displayed by the activated T cell. 1 Both activation processes are effectively down regulated by CD152 (CTLA-4) engagement.2 Human GL50 is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be a ligand for ICOS.3 ICOS-muIg recombinant protein binds to recombinant GL50-muIg in EIA. | | | Catalog # | I0649-80 | | Functional Application | ICOS-muIg binds to recombinant GL50-muIg in EIA. | | Human ICOS-muIg Fusion Protein*l | | Molecular Structure | A soluble molecule consisting of the extracellular (121aa) domain of mature human ICOS fused to the murine IgG2a Fc (232 aa). | | Transfectant Cell Line | CHO | | Applications | Suitable for use in Flow Cytometry, ELISA. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. | | | | Molecular Weight | 40.4kD | | Source | CHO cells | | Purity | Purified by affinity chromatography. | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in FBS, 50mM Sodium Phosphate pH 7.6, 100mM NaCl, 0.5 mg/ml Gentamicin Sulfate. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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