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Anti -ICOS (CD278, Inducible T cell co stimulator, Activation inducible lymphocyte immunomediatory molecule, AILIM, MGC39850) (PE)
Anti -ICOS (CD278, Inducible T cell co stimulator, Activation inducible lymphocyte
immunomediatory molecule, AILIM, MGC39850) (PE)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E FC |
|
| The inducible costimulator (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Secondary signaling through CD28 or ICOS results in discrete cytokine secretion profiles by the activated T cells.1 Signaling by either molecule is effectively down regulated by CD152 (CTLA-4) engagement.2 Human GL50 is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be the ligand for ICOS.3 Two RNA splice variants exist for this molecule, differing only in the cytoplasmic domain. 4 | | | Catalog # | I0650-01B | | Functional Application | Antibody blocks binding of Recombinant GL50-muIg to ICOS | | Applications | Suitable for use in Flow Cytometry and ELISA. Other applications not tested. | | Recommended Dilution Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only pror to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 7H152 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Human HPB-MLT cells, recombinant human ICOS-muIg | | Specificity | Binds to recombinant and cell surface ICOS. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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