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You are here:Home » Antibodies » Abs to CD Markers » Anti -ICOS (CD278, Inducible T cell co stimulator, Activation inducible lymphocyte immunomediatory molecule, AILIM, MGC39850) (PE)

Anti -ICOS (CD278, Inducible T cell co stimulator, Activation inducible lymphocyte
immunomediatory molecule, AILIM, MGC39850) (PE)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E FC
The inducible costimulator (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Secondary signaling through CD28 or ICOS results in discrete cytokine secretion profiles by the activated T cells.1 Signaling by either molecule is effectively down regulated by CD152 (CTLA-4) engagement.2 Human GL50 is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be the ligand for ICOS.3 Two RNA splice variants exist for this molecule, differing only in the cytoplasmic domain. 4
Catalog #I0650-01B
Functional Application Antibody blocks binding of Recombinant GL50-muIg to ICOS
ApplicationsSuitable for use in Flow Cytometry and ELISA. Other applications not tested.
Recommended Dilution Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only pror to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity.
Clone TypeMonoclonal
IsotypeIgG1
Clone No7H152
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman HPB-MLT cells, recombinant human ICOS-muIg
SpecificityBinds to recombinant and cell surface ICOS.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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