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You are here:Home » Antibodies » Antibodies-CD Markers » Anti -ICOS (CD278, Inducible T-cell Costimulator, Activation-inducible Lymphocyte Immunomediatory Molecule, AILIM) (APC)

Anti -ICOS (CD278, Inducible T-cell Costimulator, Activation-inducible Lymphocyte
Immunomediatory Molecule, AILIM) (APC)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
Inducible co-stimulator also called AILIM and CRP-1 (CD28-related protein-1), is a member of the CD28 family of immune co-stimulatory receptors. Other family members are CD28, CTLA-4, and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199aa with a putative 20aa signal sequence, a 121aa extracellular domain, a 23aa transmembrane region, and a 35aa cytoplasmic domain. ICOS shares ~39% aa similarity with CD28 and CTLA-4. Human and mouse ICOS share ~72% aa identity. ICOS is expressed on most CD45RO+ cells. ICOS expression is up-regulated within ~24-48h of activation on T helper (Th) primed cells. B7-H2, a member of the B7 family of co-stimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ ICOS interaction appears to play roles in T cell-dependent B cell activation and Th differentiation.
Catalog #I0650-01S
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Excitation 620-650nm
Emission 660-670nm
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.
Clone TypeMonoclonal
Clone No12K105
ConcentrationNot determined
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to human ICOS expressed in NSO cell line.
SpecificityRecognizes human ICOS.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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