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You are here:Home » Antibodies » Abs to Ligands » Anti -ICOS Ligand (CD275, Inducible T cell co-stimulator ligand, B7-H2, B7 homolog 2, B7-like protein Gl50, B7 related protein 1, B7H2, B7RP-1, B7RP1, GL50, ICOS LG , ICOSLG, KIAA0653, LICOS, Transmembrane protein B7 H2 ICOS ligand)

Anti -ICOS Ligand (CD275, Inducible T cell co-stimulator ligand, B7-H2, B7 homolog 2,
B7-like protein Gl50, B7 related protein 1, B7H2, B7RP-1, B7RP1, GL50, ICOS LG , ICOSLG,
KIAA0653, LICOS, Transmembrane protein B7 H2 ICOS ligand)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
B7-H2 is detected on the surface of monocyte derived immature dendritic cells. It is a putative ligand for ICOS (inducible costimulator) from CD28 family of T cell-costimulators. Costimulatory interactions between the B7 family ligands and their receptors like CD28, CTLA-4 and ICOS play critical role in the growth, differentiation and death of T cells. B7-H2 has four conserved structural cysteins in its extracellular domain which are believed to form the Ig V like and IgC-like domain. In addition, B7-H2 has a conserved tyrosine residue in the Ig V-like domain at position of aa80. B7-H2 shares ~46% homology at amino acid level to B7h/B7RP-1, a recently described B7 like protein of mouse origin.
Catalog #I0650-04
Applications
Suitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionsFlow Cytometry: Tested on BOSC cells transiently transfected with an ICOS Ligand expression vector.
Optimal conditions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D469
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenVector containing the cDNA of human ICOS Ligand.
SpecificityRecognizes the extracellular domain of human ICOS Ligand native protein on antigen presenting cells.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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