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You are here:Home » Antibodies » Abs to Ligands » Anti -ICOS Ligand (CD275, Inducible T cell co-stimulator ligand, B7-H2, B7 homolog 2, B7-like protein Gl50, B7 related protein 1, B7H2, B7RP-1, B7RP1, GL50, ICOS LG , ICOSLG, KIAA0653, LICOS, Transmembrane protein B7 H2 ICOS ligand)

Anti -ICOS Ligand (CD275, Inducible T cell co-stimulator ligand, B7-H2, B7 homolog 2,
B7-like protein Gl50, B7 related protein 1, B7H2, B7RP-1, B7RP1, GL50, ICOS LG , ICOSLG,
KIAA0653, LICOS, Transmembrane protein B7 H2 ICOS ligand)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E FC
The inducible co-stimulator receptor (ICOS) is a member of the CD28 receptor family that is expressed on T cells. Recently, a new ligand (ICOS ligand, ICOSL) has been identified that binds to ICOS, but not to CD28 or CTLA-4. ICOSL is constitutively expressed on monocytes, dendritic cells and B cells. Binding of ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.
Catalog #I0650-05
ApplicationsSuitable for use in Flow Cytometry and ELISA. It is expected that the antibody will be suited for all applications where recognition of the native protein is required. Other applications not tested.
Recommended DilutionFlow Cytometry: 1.2ug/10e6 cells
ELISA: 1:100-1:200
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5E511
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide, before the addition of glycerol to 40%.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman ICOSL extracellular domain (AF289028).
SpecificityRecognizes the extracellular domain of ICOSL transiently expressed on the cell surface of transfected BOSC cells as well as the native protein on antigen presenting cells (1).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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