Indolmycin CAS 21200-24-8

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I0798 Indolmycin (Antibiotic PA 155A) CAS: 21200-24-8

Specifications

References

CAS Number

21200-24-8

Grade

Highly Purified

Molecular Formula

C14H15N3O2

Molecular Weight

257.3

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Antibiotic PA 155A

Indolmycin is a highly selective antibiotic which acts as a tryptophan anti-metabolite. Recent research has shown that indolmycin is active against Mycobacteria and Helicobacter pylori and can stimulate transcription in Escherichia coli.

Purity: >99% by HPLC, mixture of diastereoisomers

Solubility: Soluble in ethanol, methanol, DMF or DMSO.

Related to: Pimprinine

Source

Streptomyces sp.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Indolmycin resistance of Streptomyces coelicolor A3(2) by induced expression of one of its two |tryptophanyl-tRNA synthetases. Kitabatake M. et al. J. Biol. Chem. 2002, 277, 23882. |2. Development of a stereoselective practical synthetic route to indolmycin, a candidate anti-H. pylori |agent. Hasuoka A. et al. Chem. Pharm. Bull. 2001, 49, 1604. |3. Indolmycin-mediated inhibition and stimulation of transcription at the trp promoter of Escherichia coli. |Bogosian G. et al. J. Bacteriol. 1983, 153, 1120.