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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E

Human IgA (immunoglobulin A) is a glycosylated protein of 160kD and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15% of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defense by neutralizing infectious agents at mucosal surfaces. The production is usually local and antigen specific. IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.
Catalog #	I1890-04B
Applications	Suitable for use in RID and ELISA. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	8L330
Host	Mouse
Source	Human
Concentration	~8mg/ml
Form	Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
Purity	Purified by Protein G affinity chromatography.
Immunogen	IgA from human colostrum. Cellular Localization: Secreted.
Specificity	Recognizes human IgA Fc region.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.