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You are here:Home » Antibodies » Abs to IgE » Anti -IgE

Anti -IgE

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified E FC
IgE is typically the least abundant isotype - blood serum IgE levels in a normal ("non-atopic") individual are ~150ng/ml, compared to 10mg/ml for the IgGs - it is capable of triggering the most powerful immune reactions. Most of our knowledge of IgE has come from research into the mechanism of a form of allergy known as type 1 hypersensitivity. There is much speculation into what physiological benefits IgE contributes, and so far, circumstantial evidence in animal models and statistical population trends have hinted that IgE may be beneficial in fighting gut parasites such as Schistosoma mansoni, but this has not been conclusively proven in humans. IgE may play an important role in the immune system's recognition of cancer, in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. IgE may be an important target in treatments for allergy and asthma.
Catalog #I1900-06N
ApplicationsSuitable for use in Flow Cytometry and ELISA. Other applications not tested.
Recommended DilutionsFlow Cytometry: 4ug/ml
ELISA: 1:2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8L344
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in TBS, pH 8.0, 15mM sodium azide
PurityPurified by Ion Exchange chromatography
ImmunogenPurified human IgE
SpecificityRecognizes human IgE. Specificity was confirmed by ELISA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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