Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Biochemicals » Biochem-Antibiotics » Ikarugamycin



  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.


Ikarugamycin is an unsual pentacyclic tetramic acid produced by Streptomyces phaeochromogenes with potent activity against the protozoan, Trichomonas vaginalis, reported in 1972. Ikarugamycin also demonstrated selective Gram positive antibacterial activity and more recently has been shown to exhibit anti-ulcer activity possibly by inhibition of Helicobacter. Investigation of the pharmacology of ikarugamycin has demonstrated a variety of actions including the inhibition of the uptake of oxidized low-density lipoprotein in mouse macrophages, blockade of PMA and Nef-mediated cell surface CD4 down-regulation and inhibition of clathrin-coated pit-mediated endocytosis. Importantly, ikarugamycin is emerging as a useful
agent for studying the process of endocytosis.
Catalog #I2300-20
Source Streptomyces sp.
Apperance White solid
Solubility Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number36531-78-9
Molecular FormulaC29H38N2O4
Molecular Weight478.6
SourceStreptomyces sp.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

External Links