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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -IkB alpha, phosphorylated (Tyr42) (NF-kappa-B Inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major Histocompatibility Complex Enhancer-binding Protein MAD3, NFKBIA, IKBA, MAD3, NFKBI)

Anti -IkB alpha, phosphorylated (Tyr42) (NF-kappa-B Inhibitor alpha, I-kappa-B-alpha,
IkB-alpha, IkappaBalpha, Major Histocompatibility Complex Enhancer-binding Protein MAD3,
NFKBIA, IKBA, MAD3, NFKBI)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E
NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a , IKK2/b, and IKK3/g. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. One of the first genes induced following NF-kB activation is IkBa.
Catalog #I2500-05B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified.
ImmunogenSynthetic phosphopeptide around Tyr42 corresponding to aa34-48 (LDSMKDEEY*EQMVKE) of human IkBa; (Genbank accession no. NP_065390.1.) (Y* refers-phosphorylated tyrosine.)
SpecificityRecognizes human IkBa when phosphorylated at Tyr42. Species Crossreactivity: monkey, mouse, porcine, bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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