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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -IkB beta, phosphorylated (Ser23) (IkappaB beta, IKBB, NFkB Inhibitor beta, NF kappa BIB, NFkBIB, Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B cells Inhibitor beta, Thyroid Receptor Interacting Protein 9, TR Interacting Protein 9, TRIP9)

Anti -IkB beta, phosphorylated (Ser23) (IkappaB beta, IKBB, NFkB Inhibitor beta, NF kappa
BIB, NFkBIB, Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B cells Inhibitor
beta, Thyroid Receptor Interacting Protein 9, TR Interacting Protein 9, TRIP9)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
NFkB exists in the cytoplasm as a complex with a 38kDa inhibitor protein, IkB (MAD-3). Activation of NFkB by different stimuli, including TNFa and PMA, requires the dissociation of the inhibitor protein. Dissociation is regulated by the phosphorylation of IkB on serine residues 32 and 36 which targets IkB for ubiquinitation and proteasome mediated degradation. The NFkB complex then translocates to the nucleus and activates transcription of responsive genes.
Catalog #I2500-09D
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry:1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human IkB-b around the phosphorylation site of serine 23 (L-G-SP-L-G ).
SpecificityRecognizes human IkB-beta when phosphorylated at serine 23. Species Cross-Reactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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