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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -IkB zeta (IkappaB zeta, IKBZ, FLJ30225, FLJ34463, INAP, Molecule Possessing Ankyrin Repeats Induced by Lipopolysaccharide, MAIL Protein, Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B cells Inhibitor zeta, NFKBIZ)

Anti -IkB zeta (IkappaB zeta, IKBZ, FLJ30225, FLJ34463, INAP, Molecule Possessing Ankyrin
Repeats Induced by Lipopolysaccharide, MAIL Protein, Nuclear Factor of kappa Light
Polypeptide Gene Enhancer in B cells Inhibitor zeta, NFKBIZ)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
IkappaB zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
Catalog #I2500-40
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1-3ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptides corresponding to aa 684-699 (RKGADPSTRNLENEQP) and 285-298 (YQYSPQTQNMQQPP) of mouse IkBz protein (NP_085115.1). Species sequence homology: human, rat, bovine, primate, (100%) chicken (73%)
SpecificityRecognizes mouse IkB zeta.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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