Anti -IkB zeta (NF-kappa-B Inhibitor zeta, I-kappa-B-zeta, IkB-zeta, IkappaBzeta, IL-1
Inducible Nuclear Ankyrin-repeat Protein, INAP, Molecule Possessing Ankyrin Repeats
Induced by Lipopolysaccharide, MAIL, NFKBIZ, IKBZ)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| IkappaBzeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes:macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65:p50 heterodimer and the p50:p50 homodimer. | | | Catalog # | I2500-40A | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1-3ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | RAW | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide. | | Purity | Purified by Protein G affinity Chromatography. | | Immunogen | Synthetic peptides corresponding to aa684-699 (RKGADPSTRNLENEQP) and 285-298 (YQYSPQTQNMQQPP) of mouse IkBz protein, GenBank no. ref|NP_085115.1. | | Specificity | Recognizes mouse IKBz. Species sequence homology: human, rat, monkey, bovine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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