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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -IkB zeta (NF-kappa-B Inhibitor zeta, I-kappa-B-zeta, IkB-zeta, IkappaBzeta, IL-1 Inducible Nuclear Ankyrin-repeat Protein, INAP, Molecule Possessing Ankyrin Repeats Induced by Lipopolysaccharide, MAIL, NFKBIZ, IKBZ)

Anti -IkB zeta (NF-kappa-B Inhibitor zeta, I-kappa-B-zeta, IkB-zeta, IkappaBzeta, IL-1
Inducible Nuclear Ankyrin-repeat Protein, INAP, Molecule Possessing Ankyrin Repeats
Induced by Lipopolysaccharide, MAIL, NFKBIZ, IKBZ)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
IkappaBzeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes:macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65:p50 heterodimer and the p50:p50 homodimer.
Catalog #I2500-40A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1-3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlRAW
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity Chromatography.
ImmunogenSynthetic peptides corresponding to aa684-699 (RKGADPSTRNLENEQP) and 285-298 (YQYSPQTQNMQQPP) of mouse IkBz protein, GenBank no. ref|NP_085115.1.
SpecificityRecognizes mouse IKBz. Species sequence homology: human, rat, monkey, bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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