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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -IKKA (Inhibitor of Nuclear Factor kappa-B Kinase Subunit alpha, I-kappa-B Kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, Conserved Helix-loop-helix Ubiquitous Kinase, I-kappa-B Kinase 1, IKK1, Nuclear Factor NF-kappa-B Inhibitor Kinase alpha, NFKB

Anti -IKKA (Inhibitor of Nuclear Factor kappa-B Kinase Subunit alpha, I-kappa-B Kinase
alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, Conserved Helix-loop-helix Ubiquitous
Kinase, I-kappa-B Kinase 1, IKK1, Nuclear Factor NF-kappa-B Inhibitor Kinase alpha, NFKB

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
IKKa (IkB kinase-a or IKK-1) is part of a large protein complex responsible for the inducible phosphorylation of IkB proteins. Human IKK-a is an 85kD peptide that has been shown to activate NFkB by phosphorylation of IkB proteins. IKKa interacts with its upstream kinase, NIK, and its downstream substrate, the IkB proteins. Mutations of IKKa in its kinase domain lead to a dominant-negative phenotype that suppresses TNF-a and IL-1b induced NFkB activation.
Catalog #I3000-01H
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Immunoprecipitation: 4-8ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 1% BSA, 0.02% thimerosal, 50% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant protein corresponding to human IKKa expressed in E. coli.
SpecificityRecognizes human IKKa.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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