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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -IKK beta (IkappaB Kinase beta, IKKb, IKK2, IkBKb, IkappaB Kinase 2, Inhibitor of kappa Light Chain Gene Enhancer in B cells, Inhibitor of kappa Light Polypeptide Gene Enhancer in B cells Kinase beta, Inhibitor of Nuclear Factor kappa B Kinase beta, MGC131

Anti -IKK beta (IkappaB Kinase beta, IKKb, IKK2, IkBKb, IkappaB Kinase 2, Inhibitor of
kappa Light Chain Gene Enhancer in B cells, Inhibitor of kappa Light Polypeptide Gene
Enhancer in B cells Kinase beta, Inhibitor of Nuclear Factor kappa B Kinase beta, MGC131

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IP
NFkB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death. In the cytoplasm NFk B is negatively modulated by the inhibitory proteins Ik-B. In turn Ik-B is phosphorylated by a cellular kinase complex called IKK. IKK is a heterodimer composed of two kinases: IKK-a and IKK-b which phosphorylate Ik-B leading to its degradation and the resulting translocation of NFk B to the nucleus. IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF-a , endotoxins and overexpression of cellular kinases like MEKK1. Aspirin appears to have its effect by inhibiting the binding of ATP to IKK.
Catalog #I3000-08G
Cellular Localization Cytoplasmic
ApplicationsSuitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormAs reported
PurityWhole antisera
ImmunogenSynthetic peptide conjugated to KLH- which corresponds to the highly conserved C-terminus region of the human protein. Epitope: Recognition is at the highly conserved C-terminal region.
SpecificityControl peptide will compete only with the specific reaction of antiserum with the IKKb subunit. Species Crossreactivity: Crossreacts with Human, Mouse and Rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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