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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -IKKB, C3 (Inhibitor Of Nuclear Factor kappa B Kinase beta Subunit, I-kappa-B-kinase beta, IkBKB, IKK-beta, IKK-B, I-kappa-B Kinase 2, IKK2, Nuclear Factor NF-kappa-B Inhibitor Kinase beta, NFKBIKB, IKBKB)

Anti -IKKB, C3 (Inhibitor Of Nuclear Factor kappa B Kinase beta Subunit, I-kappa-B-kinase
beta, IkBKB, IKK-beta, IKK-B, I-kappa-B Kinase 2, IKK2, Nuclear Factor NF-kappa-B
Inhibitor Kinase beta, NFKBIKB, IKBKB)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IC IF
Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa, and bacteria product LPS. NF-kB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. The long-sought IkB kinase (IKK), which phosphorylates IkB, and mediates IkB degradation and NF-kB activation, was recently identified by several laboratories (1-5). IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKa and IKKb). IKKa and IKKb interact with each other and both are essential for NF-kB activation. IKKb phosphorylates both IkB-a and IkB-b. IKKb is expressed in variety of human tissues.
Catalog #I3000-25A
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 10ug/ml
Western Blot: 1-2ug/ml
Immunocytochemistry: 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa662-680 of human IKKb, which differs from corresponding murine sequence by one aa.
SpecificityRecognizes human IKKb (C3).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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