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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -IKK beta, phosphorylated (Tyr199) (IkappaB Kinase beta, IKKb, IKK2, IkBKb, IkappaB Kinase 2, Inhibitor of kappa Light Chain Gene Enhancer in B cells, Inhibitor of kappa Light Polypeptide Gene Enhancer in B cells Kinase beta, Inhibitor of Nuclear Factor ka

Anti -IKK beta, phosphorylated (Tyr199) (IkappaB Kinase beta, IKKb, IKK2, IkBKb, IkappaB
Kinase 2, Inhibitor of kappa Light Chain Gene Enhancer in B cells, Inhibitor of kappa
Light Polypeptide Gene Enhancer in B cells Kinase beta, Inhibitor of Nuclear Factor ka

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IF
IKK-beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
Catalog #I3000-27G
ApplicationsSuitable for use in Immunofluorescence. Other applications not tested.
Recommended DilutionImmunofluorescence:1:100-1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human IKK-beta around the phosphorylation site of tyrosine 199 (Q-K-YP-T-V).
SpecificityRecognizes IKK-beta when phosphorylated at tyreonine 199. Species Cross-Reactivity: human, mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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