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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -IKKB, CT (Inhibitor Of Nuclear Factor kappa B Kinase beta Subunit, I-kappa-B-kinase beta, IkBKB, IKK-beta, IKK-B, I-kappa-B Kinase 2, IKK2, Nuclear Factor NF-kappa-B Inhibitor Kinase beta, NFKBIKB, IKBKB)

Anti -IKKB, CT (Inhibitor Of Nuclear Factor kappa B Kinase beta Subunit, I-kappa-B-kinase
beta, IkBKB, IKK-beta, IKK-B, I-kappa-B Kinase 2, IKK2, Nuclear Factor NF-kappa-B
Inhibitor Kinase beta, NFKBIKB, IKBKB)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IP IH IF
IKKbeta, an IKAPPAB -type protein kinase, is a member of the multimeric IkappaB kinase complex. This complex, often consisting of IKKalpha/IKKbeta heterodimers plus regulatory IKKgamma subunits, phosphorylates IkappaB proteins, marking them for destruction and thereby allowing activation of NFkappaB and downstream nuclear genes. The constitutively expressed IKKbeta protein contains an N-terminal kinase domain, a central leucine zipper motif, and a C-terminal helix-loop-helix motif. In knockout studies, IKKbeta (-/-) mice died between embryonic day 12.5 and 14 due to extensive liver damage from apoptosis; however, they were rescued by inactivation of the tumor necrosis factor receptor 1 gene. IKKbeta has been implicated in the pathogenesis of insulin resistance in obesity and type II diabetes mellitus.
Catalog #I3000-27J
ApplicationsSuitable for use in ELISA, Immunoprecipitation, Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.1% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to of human IKBKB, at C-terminal (KLH).
SpecificityRecognizes human IKBKB.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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