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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » Interleukin 1 Receptor AcP, Blocking Peptide (IL1RacP, IL-1 Receptor Accessory Protein)

Interleukin 1 Receptor AcP, Blocking Peptide (IL1RacP, IL-1 Receptor Accessory Protein)

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Specifications

Peptide corresponding to amino acids 549 to 569 of human IL-1RAcP, which differs from the sequence of mouse origin by three amino acids (1).
The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) (1). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kB inducing kinae (NIK) and of NF-kB, recruits to the IL-1R complex through IL-1RAcP (2). IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP (3,4). Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.
Catalog #I5000P
SourceSynthetic peptide
PurityPurified 60-70%
Concentration0.2mg/ml
FormSupplied as a lyophilized powder.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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