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Interleukin 1 Receptor AcP, Blocking Peptide (IL1RacP, IL-1 Receptor Accessory Protein)
Interleukin 1 Receptor AcP, Blocking Peptide (IL1RacP, IL-1 Receptor Accessory Protein)
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| Peptide corresponding to amino acids 549 to 569 of human IL-1RAcP, which differs from the sequence of mouse origin by three amino acids (1). | | | The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) (1). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kB inducing kinae (NIK) and of NF-kB, recruits to the IL-1R complex through IL-1RAcP (2). IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP (3,4). Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues. | | | Catalog # | I5000P | | Source | Synthetic peptide | | Purity | Purified 60-70% | | Concentration | 0.2mg/ml | | Form | Supplied as a lyophilized powder. | | | Important Note | This product is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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