| Immunoglobulin Superfamily, member 4C (IGSF4C), also known as Nectin-like protein 4 (Necl-4), SynCAM4, or TSLL-2, is a type I transmembrane glycoprotein adhesion molecule. Expression at 55kD in epithelia of kidney, bladder and prostate, 52kD in brain, and 50 or 48kD in the testes may be due to variable glycosylation. IGSF4C participates in Ca2+-independent, mainly homophilic cell-cell adhesion activity and is a proposed tumor suppressor. Human IGSF4C contains a 306aa extracellular region with one V-type and two C2-type Ig-like domains. Human IGSF4C shares 98-99% amino acid identity with mouse, rat, dog and bovine IGSF4C. |
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| Catalog # | I7502-70C1 |
| Applications | Suitable for use in Direct ELISA and Immunohistochemistry. Other applications not tested. |
| Recommended Dilution | Direct ELISA: 0.5-1.0ug/ml; The detection limit is ~3ng/well. |
| Immunohistochemistry (Paraffin): 15ug/ml |
| Optimal dilutions to be determined by the researcher. |
| Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
| CAS Number | n/a |
| Clone Type | Monoclonal |
| Isotype | IgG1 |
| Clone No | 8H173 |
| Host | Rat |
| Source | Human |
| Concentration | ~0.5mg/ml |
| Form | Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS. |
| Purity | Purified by Protein G affinity chromatography. |
| Immunogen | NS0-derived recombinant human IGSF4C. (aa25-323) |
| Specificity | Recognizes human Immunoglobulin Superfamily Member 4C (IGSF4C). Does not crossreact with rmIGSF4A, rhIGSF3, rhIGSF4B, rhIGSF4D or rhIGSF8 in Direct ELISAs. |
| Species Sequence Homolgy (98-99%) | Mouse, rat, canine and bovine |
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| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
| Alternate names | SynCAM4 |
