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You are here:Home » Antibodies » Abs to Infectious Disease Influenza » Anti -Influenza A H5N1 (Avian) Nonstructural Protein 1 (NS1)

Anti -Influenza A H5N1 (Avian) Nonstructural Protein 1 (NS1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
The NS1 protein of influenza A virus (NS1A protein) is a multifunctional protein that counters cellular antiviral activities and is a virulence factor. The influenza protein NS1 is a 26,000 Dalton protein. Human messenger RNA carries a poly-A tail at the 5' end. NS1 forms a dimer that inhibits the export of poly-A containing mRNA molecules from the nucleus. This gives preference to viral RNA which is transported to the ribosome to be translated. NS1 might also inhibit splicing of pre-mRNA by binding to a stem-bulge region in U6 small nuclear RNA (snRNA). In addition, NS1 is probably able to suppress the interferon response in the virus-infected cell leading to unimpaired virus production. NS1 also binds dsRNA. The NS1 protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast Asia is currently believed to be responsible for the enhanced virulence of the strain. H5N1 NS1 is characterized by a single amino acid change at position 92. By changing the amino acid from glutamic acid to aspartic acid, researchers were able to annul the effect of the H5N1 NS1. This single amino acid change in the NS1 gene greatly increased the pathogenicity of the H5N1 influenza virus.
Catalog #I7649-52
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 14aa in the carboxy terminus of the NS1 protein (Genbank No. ABC72653).
SpecificityRecognizes Nonstructural protein 1 (NS1) from an H5N1 strain of avian influenza A.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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