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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E B

The nucleoprotein (NP) of Influenza virus encapsulates the negative strand of the viral RNA and is essential for replicative transcription. It may also be involved in other essential functions throughout the virus life cycle. As well as binding ssRNA, NP is able to self associate to form large oligomeric complexes. NP is able to interact with a variety of other macromolecules of both viral and cellular origins. It binds the PB1 and PB2 subunits of the polymerase and the matrix protein M1. "NP has also been shown to interact with at least four cellular polypeptide families: nuclear import receptors of the importin class, filamentous (F) actin, the nuclear export receptor CRM1 and a DEAD box helicase BAT1/UAP56" (Portela, et al. 2002).
Catalog #	I7650-83D
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilutions	Western Blot: 1-3ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Recombinant Influenza A virus segment 5 nuclear protein.
Strain	A/Puerto Rico/8/34/Mount Sinai (H1N1).
Specificity	Reognizes human Influenza A, Nucleoprotein.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	NP-A