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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -ING1, p33 (Inhibitor of Growth 1)

Anti -ING1, p33 (Inhibitor of Growth 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IF
The p33ING1 protein encodes a 33-kD, 294-amino acid protein that displays the characteristics of a tumor suppressor gene. The p33ING1 protein is a regulator of cell cycle, senescence, and apoptosis. It can mediate growth arrest, anchor dependent growth and influence chemosensitivity (1-4). It also has a proposed role as a growth regulator, which is consistent with its location in the nucleus (5). It has been demonstrated that the ING1 gene has three exons and that four mRNA variants are transcribed from three different promoter regions (p33 ING1, p24 ING1, p27 ING1, p47 IG1) (6, 7). ING1 can possibly influence the above biological functions depending on which variant is expressed (1-4).
Catalog #I7652-50D
ApplicationsSuitable for use in Western Blot, ELISA and Immunofluorescence. Other applications not tested.
Recommended DilutionWestern Blot: 0.25mg/ml was sufficient for detection in lysates prepared from human melanoma cell lines by Western Blot analysis.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.25mg/ml
FormSupplied as a liquid in TBS, 0.1% sodium azide.
PuritySerum
ImmunogenMouse p33 ING1 N-terminal peptide –KLH conjugates
SpecificityDetects a ~33kD protein, corresponding to the apparent molecular mass of p33 ING1 on SDS-PAGE immunoblots. Species Crossreactivity: Human and Mouse. Not crossreactive with any other ING family.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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