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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -ING1, p33 (Inhibitor of Growth 1)

Anti -ING1, p33 (Inhibitor of Growth 1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
The ING1 (inhibitor of growth) tumor suppressor protein shares a number of biological functions that are very similar with p53. The human ING1 gene contains three exons and two introns. There are four alternative splice variants produced from three different promoter regions (p33 ING1, p24 ING1, p27 ING1, p47 ING1). A number of studies have concluded that ING1 can influence a number of biological functions, which might be dependent on the variant that is expressed. The ING1 family has been reported to mediate growth arrest, senescence, anchorage-dependent growth and apoptosis, as well as influence chemosensitivity.
Catalog #I7652-51
ApplicationsSuitable for use in ELISA and Western Blotting. Other applications not tested.
Recommended DilutionELISA: 1:4000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No5i109
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman p33 ING1.
SpecificityRecognizes the tumor supressor p33 ING1, this protein cooperates with p53 protein in the negative regulatory pathway of cell growth by modulating p53-dependent transcription activation.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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