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You are here:Home » Antibodies » Abs to Insulin » Anti -Insulin (Biotin)

Anti -Insulin (Biotin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B-cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B-cell origin such as insulinoma.
Catalog #I7656-10
ApplicationsSuitable for use in detection of insulin in two-site enzyme immunoassay. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
HybridomaHybridization of X63-Ag8-653 myeloma cells with spleen cells from Balb/c mice.
Affinity Constant8.0x10e8L/mole
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No2B60
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 20mM Tris-HCl, pH 7.5, 150mM sodium chloride, 0.1% sodium azide. Labeled with Biotin.
PurityPurified by Protein A affinity chromatography. Purity is tested by electrophoresis.
ImmunogenPurified human insulin
SpecificityRecognizes human insulin. Crossreacts with human proinsulin, bovine insulin (30%) and porcine insulin. No crossreaction with free C-peptide.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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