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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified IH

Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B-cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B-cell origin such as insulinoma.
Catalog #	I7656-15
Applications	Suitable for use in Immunohistochemistry and ELISA. Other applications not tested.
Recommended Dilution	Immunohistochemistry: Frozen sections
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1,k
Clone No	4i333
Host	Mouse
Source	Human
Concentration	~2mg/ml
Form	Supplied in PBS, pH 7.4, 0.1% sodium azide. Glycerol free.
Purity	Purified by Protein A affinity chromatography.
Immunogen	Purified full length native human insulin
Specificity	Reacts with human insulin and proinsulin. Also reacts with bovine and porcine insulin.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.