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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E B IP IH

Insulin (INS) is a hormone central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin (INS) to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified.
Catalog #	I7660-09E
Applications	Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended Dilution	Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
	Optimal dilutions to be determined by the researcher.
Hybridoma	Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1,k
Clone No	2D11.H5
Host	Mouse
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in 0.02M potassium phosphate, 0.5M sodium chloride, pH 7.2, 0.01% sodium azide.
Purity	Purified by Protein A affinity chromatography.
Immunogen	Human INS fusion protein
Specificity	Recognizes human INS.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.