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You are here:Home » Antibodies » Antibodies-Insulin » Anti -Insulin (INS)

Anti -Insulin (INS)


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Clone Host Grade Applications
Monoclonal Mouse Ascites IH
Insulin is a polypeptide hormone that is produced by beta cells in the islets of langerhans glands, located in the pancreas. It controls the level of the sugar glucose in the blood. The insulin mRNA is translated as a single chain precursor called preproinsulin, and removal of its signal peptide during insertion into the endoplasmic reticulum generates proinsulin. Proinsulin consists of three domains: an amino-terminal B chain, a carboxy-terminal A chain and a connecting peptide in the middle known as the C peptide. Within the endoplasmic reticulum, proinsulin is exposed to several specific endopeptidases which excise the C peptide, thereby generating the mature form of insulin. Apart from its primary role in glucose uptake, it allows the transport ofaa into cells, has anabolic functions like stimulation of glucose oxidation, protein synthesis, RNA synthesis, fatty acid synthesis, and glycosaminoglycan synthesis. It also activates fat formation and helps to improve nitrogen retention. Deficiency of insulin results in diabetes mellitus.
Catalog #I7660-30M
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:25-1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No11E229
ConcentrationNot determined
FormSupplied as a liquid.
SpecificityRecognizes insulin. Species Crossreactivity: bovine, porcine, feline, canine, guinea pig, rabbit, rat, sheep.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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