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Insulin-Like Growth Factor I, Recombinant, Human (IGF1)
Insulin-Like Growth Factor I, Recombinant, Human (IGF1)
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| The Insulin-like growth factor-1 (IGF-1) is mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGF-1 is predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGF-1 belongs to the insulin gene family, which also contains insulin and relaxin. The IGF-1 is similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. This recombinant human IGF-I is globular protein containing 71 amino acids, and 3 intra-molecular disulfide bonds. Recombinant IGF-1 was expressed in E. coli. | | | | | | AA Sequence: | | | MGPETLCGAE LVDALQFVCG DRGFYFNKPT GYGSSSRRAP QTGIVDECCF RSCDLRRLEM YCAPLKPAKS A | | | Catalog # | I7661-09J | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, Aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 7.7kD | | Source | Recombinant, Human, (E. coli) | | Purity | 95% by SDS-PAGE. Purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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