You are here:Home
»
Growth Factors, Cytokines
»
Growth Factors-IGF
»
Insulin-Like Growth Factor I, Recombinant, Human (IGF1, IGF I) (Liquid)
Insulin-Like Growth Factor I, Recombinant, Human (IGF1, IGF I) (Liquid)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Insulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor which stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Recombinant Human IGF-I is a single, nonglycosylated, 7.6kD protein containing 70 amino acid residues. Insulin-like growth factor 1 (IGF-I) is involved in regulation of neuronal growth and development in central and peripheral nervous system. It is known to protect neurons against cell death induced by amyloidogenic derivatives, glucose or serum | | | deprivation through pathways involving AKT kinase and transcription factor FKHRL1 phosphorylation. Activation of the insulin-like growth factor system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like breast and thyroid cancers | | | Catalog # | I7661-11C | | Biological Activity | Human IGF-I is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent proliferation of murine BALB/c 3T3 cells (measured by 3H-thymidine uptake) is 1ng/ml, corresponding to a specific activity of 1x10e6 units/mg. For most in vitro applications, IGF1 exerts its biological activity in the concentration range of 0.2-20ng/ml. | | Responding Cells (partial list) | Bone, muscle cells, CHO cells | | AA Sequence | GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 7.6kD | | Source | Recombinant, Human (E. coli) | | Purity | 98% by SDS-PAGE and HPLC analyses. Endotoxin: 0.1ng/ug (1EU/ug) | | Concentration | ~1mg/ml | | Form | Supplied as a lliquid in 50mM acetic acid, 0.1% BSA.. Available as a lyophilized powder, see I7661-11. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
