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You are here:Home » Molecular Biology » Growth Factors-IGF » Insulin-Like Growth Factor Binding Protein 1, Calibrator Grade, Human

Insulin-Like Growth Factor Binding Protein 1, Calibrator Grade, Human

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Specifications

IGFBP-1 is one of the six homologous proteins that specifically bind insulin-like growth factors and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. Insulin-Like Growth Factor Binding Protein modulates IGF activities by increasing their plasma half lives and by inhibiting or promoting the interactions of IGF with receptors on certain target cells. In addition these binding proteins provide a reservoir for IGF in pericellular spaces. Some IGF-BPs also have stimulating effects in vitro and some may inhibit the growth of cells.
Catalog #I7661-16B4
Source
Pooled Amniotic Fluid (3rd trimester of pregnancy)
ApplicationsSuitable for use as a calibrator or standard in immunoassay. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceAmniotic Fluid
PurityPurified by Ion-exchange, metal-chelate and hydrophobic chromatography
FormSupplied as a lyophilized powder. No preservative added. Reconstitute in distilled water to desired concentration.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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