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I7661-16C Insulin-Like Growth Factor Binding Protein 4, Recombinant, Human (IGFBP4, BP-4, HT29-IGFBP, IBP4) CAS:

Specifications
References
Grade
Purified
Molecular Weight
24
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and several low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF.

Source
yeast
Biological Activity
Binding activity of human IGF-BP 4 is determined by the inhibition activity of both IGF I and II.
Storage and Stability
Lyophilized powder may be stored at -20°C. Reconstitute to with sterile dH2O or buffer, aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, Yeast
Purity
Purified. ≥ 90% pure by SDS gel electrophoresis.
Concentration
As reported
Form
Supplied as a lyophilized powder in PBS
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Rechler M.M. and Brown A.L. (1992) Growth Regulation, 2, 55. 2. Modern Concepts of Insulin-Like Growth Factor. Ed. E. Martin Spencer, M.D. (1991). Elsevier Science Publ., pages 311-415
USBio References
No references available
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