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You are here:Home » Molecular Biology » Growth Factors-IGF » Insulin-Like Growth Factor Binding Protein 5, Recombinant, Human (IGFBP5, IBP5, IBP-5)

Insulin-Like Growth Factor Binding Protein 5, Recombinant, Human (IGFBP5, IBP5, IBP-5)

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Specifications

Human IGF-BP5 is a 28.6kD cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Studies show that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole body growth inhibition, and retarded muscle development. Recombinant human IGF-BP5 is a 28.6kD protein consisting of 253 amino acid residues.
Catalog #I7661-16T4
Source E.coli
Endotoxin 0.1ng/ug
Biological Activity The ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is 0.3ug/ml, in the presence of 15ng/ml of human IGF-II.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Stable for at least 6 months at -20°C. Reconstitute with sterile ddH2O, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight28.6kD
SourceE. coli
Purity98% (SDS-PAGE and HPLC)
ConcentrationNot determined
FormSupplied as a lyophilized powder from 10mM Sodium Citrate solution, pH 3.0. Reconstitute in ddH2O to 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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