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Insulin-Like Growth Factor Binding Protein 5, Recombinant, Human (IGFBP5, IBP5, IBP-5)
Insulin-Like Growth Factor Binding Protein 5, Recombinant, Human (IGFBP5, IBP5, IBP-5)
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| Human IGF-BP5 is a 28.6kD cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Studies show that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole body growth inhibition, and retarded muscle development. Recombinant human IGF-BP5 is a 28.6kD protein consisting of 253 amino acid residues. | | | Catalog # | I7661-16T4 | | Source | E.coli | | Endotoxin | 0.1ng/ug | | Biological Activity | The ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is 0.3ug/ml, in the presence of 15ng/ml of human IGF-II. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Stable for at least 6 months at -20°C. Reconstitute with sterile ddH2O, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 28.6kD | | Source | E. coli | | Purity | 98% (SDS-PAGE and HPLC) | | Concentration | Not determined | | Form | Supplied as a lyophilized powder from 10mM Sodium Citrate solution, pH 3.0. Reconstitute in ddH2O to 0.1-1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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